Male hypogonadism (low testosterone levels confirmed by tests)Delayed puberty in males (rare; specialist-guided)Certain types of male infertility (hormone-related)Gender-affirming hormone therapy in transgender men (supervised by endocrinologist)Andropause symptoms (low energy, low libido, muscle loss — if due to low testosterone)Treatment of osteoporosis secondary to androgen deficiency
Contraindications:
Prostate cancer or suspected cancerMale breast cancerSevere heart, liver, or kidney diseaseHigh calcium levelsUncontrolled heart failureSleep apnea (untreated)History of blood clot disordersPregnancy or breastfeeding (absolutely contraindicated)Allergy to testosterone or sesame oil (vehicle)
Side Effects:
CommonAcne, oily skinIncreased body hairMood changes, irritabilitySwelling of legs due to fluid retentionIncrease in red blood cells (Polycythemia)Injection-site painSeriousProstate enlargement, urinary difficultiesBlood clotsGynecomastia (breast enlargement)Liver strain or abnormalitiesSleep apnea worseningHigh blood pressureInfertility (testosterone can reduce sperm count)Seek urgent care if:Chest painSudden shortness of breathSevere swelling of feetJaundice
Precautions:
Use ONLY with regular monitoring:Testosterone levelsCBC (blood count)Liver function testsPSA (prostate-specific antigen) in men over 40Lipid profileMonitor for mood changes and aggressionAvoid in those trying to conceive (reduces sperm production)
Dietary Restrictions:
No strict restrictions, but recommended:Avoid alcohol (strain on liver & worsens hormonal imbalance)Maintain low-fat, heart-healthy diet → testosterone can increase cholesterolStay hydratedAvoid high-salt diet if fluid retention occursAvoid bodybuilding supplements containing hormones
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