Used For:

• Systemic & Mucocutaneous Fungal Infections

Contraindications:

• Hypersensitivity to fluconazole or other azole antifungals Concomitant use with drugs like cisapride, terfenadine, astemizole, erythromycin, or pimozide (risk of QT prolongation) Severe liver disease Pregnancy (especially in high doses or long-term therapy) — may cause fetal harm Lactation (passes into breast milk; occasional single-dose use may be acceptable under supervision)

Side Effects:

• Nausea, vomiting, abdominal pain Headache or dizziness Skin rash Diarrhea Mild elevation in liver enzymes

Precautions:

• Monitor liver function in patients on long-term or high-dose therapy. Use cautiously in renal impairment (dose adjustment needed if creatinine clearance <50 mL/min). Avoid concurrent use of drugs that prolong QT interval. Avoid long-term use without medical supervision. Pregnant or breastfeeding women: Use only if benefits outweigh risks.

Dietary Restrictions:

• Can be taken with or without food; food does not affect absorption. Avoid alcohol – increases risk of liver toxicity. Stay hydrated — helps with drug metabolism and reduces nausea. Avoid grapefruit juice (may interfere with metabolism, though minor effect). Do not take other antifungal or hepatotoxic drugs unless prescribed.