Used For:

• Treatment and prevention of fungal infections

Contraindications:

• Hypersensitivity to fluconazole or other azole antifungalsCo-administration with drugs that prolong QT interval (risk of arrhythmias)Severe hepatic impairment without monitoringPregnancy (especially first trimester) — only if benefits outweigh risksLactation — use with caution

Side Effects:

• Gastrointestinal: Nausea, vomiting, diarrhea, abdominal painCNS: Headache, dizzinessSkin: Rash, pruritusHepatic: Mild increase in liver enzymes

Precautions:

• Monitor liver function tests if therapy is prolonged (>2 weeks)Caution in patients with renal impairment; dose adjustment may be neededMonitor electrolytes and ECG if patient is on other QT-prolonging drugsAvoid self-medication — must be prescribed for confirmed fungal infectionInteractions: Fluconazole inhibits CYP3A4 and CYP2C9 → increases levels of warfarin, phenytoin, sulfonylureas, and some statins

Dietary Restrictions:

• No strict food restrictionsCan be taken with or without foodAvoid excessive alcohol — may increase liver stressMaintain hydration during therapyCheck with physician before taking herbal supplements (St. John’s Wort may reduce efficacy)